While very low-depend MBL seldom progresses to CLL, large-count MBL progresses to CLL demanding therapy in a level of one% to two% per annum. Substantial-depend MBL is distinguished from Rai 0 CLL based upon whether the B-cell count is above or beneath 5 × 109/L. Even though persons with both higher-rely MBL and CLL Rai stage 0 are at enhanced cha